Medicine : Cortasthma

Name:Cortasthma
Type:Tablet
Manufacturer:Zydus Cadila
Generic Use:Phenobarbitone , Ephedrine , Aminophylline
Composition:Phenobarbitone(15 Mg) , Ephedrine(25 Mg) , Aminophylline(100 Mg)
Substitutes:cortasthma , cortasthma , cortasthma


Generic ( Phenobarbitone )



Typical use Of Phenobarbitone :Benign Febrile Convulsions Of Infancy, Epilepsy, Seizures, Short-term Treatment Of Severe Congestive Heart Failure, Status Epilepticus.
Mechanism of action of Phenobarbitone :Phenobarbital Acts On GABA A Receptors, Increasing Synaptic Inhibition. Phenobarbital May Also Inhibit Calcium Channels, Resulting In A Decrease In Excitatory Transmitter Release. The Sedative-hypnotic Effects Of Phenobarbital Are Likely The Result Of Its Effect On The Polysynaptic Midbrain Reticular Formation, Which Controls CNS Arousal.
Drug Interaction of Phenobarbitone :Phenobarbitone Is Known To Interact With Other Drugs Like Abacavir, Alcohol, Alfacalcidol, Amoxapine, Bupropion (HCl), Calcifediol, Carbamazepine, Carmustine, Chloramphenicol, Chlorpropamide, Clonazepam, Corticotropin, Cyclosporin A, Desogestrel, Dexamethasone, Dexamphetamine (Sulphate), Dextropropoxyphene, Di-Iodohydroxyquinoline, Diazepam, Digitoxin, Diltiazem (HCl), Dimemorfan Phosphate, Dipyrone, Disopyramide, Doxycycline, Dydrogesterone, Ephedrine, Estazolam, Estradiol (Valerate), Ethinyloestradiol, Ethosuximide, Ethynodiol (Diacetate), Flunisolide, Fosphenytoin, Gallopamil, Gestodene, Griseofulvin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Phenobarbitone :Ataxia, Confusion, Aggression, Irritability, Nystagmus, Mental Disturbances, Agranulocytosis, Aplastic Anemia, Exfoliative Dermatitis, Hepatitis, Skin Rashes, Erythema, Morbiliform.

INTERACTIONS OF PHENOBARBITONE


How Phenobarbitone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Phenobarbitone will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Phenobarbitone

No Studies Found






Generic ( Ephedrine )



Typical use Of Ephedrine :Mild Chronic Bronchial Asthma.Epidural Anaesthesia-induced Hypotension.
Mechanism of action of Ephedrine :Ephedrine Is A Sympathomimetic Amine - That Is, Its Principal Mechanism Of Action Relies On Its Direct And Indirect Actions On The Adrenergic Receptor System, Which Is Part Of The Sympathetic Nervous System.Ephedrine's Action As An Agonist At Most Major Noradrenaline Receptors And Its Ability To Increase The Release Of Both Dopamine And To A Lesser Extent, Serotonin By The Same Mechanism Is Presumed To Have A Major Role In Its Mechanism Of Action.
Drug Interaction of Ephedrine :Do Not Start Or Stop The Medicine Without Doctor Or Pharmacist Approval.
Side effects of Ephedrine :The Severe Or Irreversible Adverse Effects Of Ephedrine, Which Give Rise To Further Complications Include Psychosis, Cardiopathy.Ephedrine Produces Potentially Life-threatening Effects Which Include Acute Cardiovascular Stimulation. Which Are Responsible For The Discontinuation Of Ephedrine Therapy.

INTERACTIONS OF EPHEDRINE


How Ephedrine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Ephedrine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ephedrine

No Studies Found






Generic ( Aminophylline )



Typical use Of Aminophylline :Acute Severe Asthma, Asthma, Obstructive Airway Disease, Reversible Airways Obstruction.
Mechanism of action of Aminophylline :Aminophylline Is The Ethylenediamine Salt Of Theophylline. After Ingestion, Theophylline Is Released From Aminophylline, And Theophylline Relaxes The Smooth Muscle Of The Bronchial Airways And Pulmonary Blood Vessels And Reduces Airway Responsiveness To Histamine, Methacholine, Adenosine, And Allergen. Theophylline Competitively Inhibits Type III And Type IV Phosphodiesterase (PDE), The Enzyme Responsible For Breaking Down Cyclic AMP In Smooth Muscle Cells, Possibly Resulting In Bronchodilation. Theophylline Also Binds To The Adenosine A2B Receptor And Blocks Adenosine Mediated Bronchoconstriction. In Inflammatory States, Theophylline Activates Histone Deacetylase To Prevent Transcription Of Inflammatory Genes That Require The Acetylation Of Histones For Transcription To Begin.
Drug Interaction of Aminophylline :Aminophylline Is Known To Interact With Other Drugs Like Allopurinol, Ascorbic Acid, Cimetidine (HCl), Disulfiram, Fluvoxamine (Maleate), Halothane, Interferon Alpha, Ketamine (HCl), Metipranolol, Metrizamide, Obidoxime (Cl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Aminophylline :Convulsions, Hypoglycemia, Hypovolemia, Dizziness, Headache, Diarrhea, Anxiety, Restlessness, Palpitation, Tachycardia, Tremors, Insomnia, Abdominal Pain.

INTERACTIONS OF AMINOPHYLLINE


How Aminophylline will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Aminophylline will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Aminophylline

No Studies Found