Medicine : Colotecan (40mg)

Name:Colotecan (40mg)
Manufacturer:Sun Pharmaceutical Industries Ltd
Generic Use:Irinotecan Hydrochloride Trihydrate
Composition:Irinotecan Hydrochloride Trihydrate(40 Mg)

Generic ( Irinotecan Hydrochloride Trihydrate )

Typical use Of Irinotecan Hydrochloride Trihydrate :For The Treatment Of Metastatic Colorectal Cancer, Also Used In Combination With Cisplatin For The Treatment Of Extensive Small Cell Lung Cancer.
Mechanism of action of Irinotecan Hydrochloride Trihydrate :Irinotecan Inhibits The Action Of Topoisomerase I. Irinotecan Prevents Religation Of The DNA Strand By Binding To Topoisomerase I-DNA Complex. The Formation Of This Ternary Complex Interferes With The Moving Replication Fork, Which Induces Replication Arrest And Lethal Double-stranded Breaks In DNA. As A Result, DNA Damage Is Not Efficiently Repaired And Apoptosis (programmed Cell Death) Occurs.
Drug Interaction of Irinotecan Hydrochloride Trihydrate :Irinotecan Hydrochloride Trihydrate Is Known To Interact With Other Drugs Like Dexamethasone, Prochlorperazine, Ketoconazole, Atazanavir Sulfate, Laxatives, Diuretics. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Irinotecan Hydrochloride Trihydrate :Diarrhoea, Nausea, Vomiting Constipation, Neutropenia, Anaemia, Thrombocytopenia, Fever, Asthenia, Acute Cholinergic Syndrome, Infections And Alopecia.


How Irinotecan Hydrochloride Trihydrate will impact on Pregnancy ?

Information Not Available.

How Irinotecan Hydrochloride Trihydrate will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Irinotecan Hydrochloride Trihydrate

Information Not Available.