Medicine : Chloromycetin Applicaps

Name:Chloromycetin Applicaps
Type:Capsule
Manufacturer:Pfizer Ltd (parke-davis)
Generic Use:Chloramphenicol
Composition:Chloramphenicol(1 % W/w X 50's)
Substitutes:chloromycetin applicaps , chloromycetin ear drops


Generic ( Chloramphenicol )



Typical use Of Chloramphenicol :Enteric Fever (Typhoid And Para Typhoid).H.Influenzae Meningitis. Anaerobic Infections, Intraocular Infections, Urinary Tract Infections, Conjunctivitis, External Ear Infections.Corneal Ulcer, Bacterial Conjunctivitis, Trachoma, Ocular Infections.Otitis Externa, Chronic Otitis Media. Pre And Post Antral Or Mastoid Surgery.
Mechanism of action of Chloramphenicol :Chloramphenicol Is Lipid-soluble, Allowing It To Diffuse Through The Bacterial Cell Membrane. It Then Reversibly Binds To The L16 Protein Of The 50S Subunit Of Bacterial Ribosomes, Where Transfer Of Amino Acids To Growing Peptide Chains Is Prevented (perhaps By Suppression Of Peptidyl Transferase Activity), Thus Inhibiting Peptide Bond Formation And Subsequent Protein Synthesis.
Drug Interaction of Chloramphenicol :Chloramphenicol Is Known To Interact With Other Drugs Like Amoxicillin, Ampicillin, Ascorbic Acid, Azlocillin (Na), Bacampicillin, Benzathine Penicillin, Carbenicillin (Na), Chlorpropamide, Chymotrypsin, Cimetidine (HCl), Ciprofloxacin, Cloxacillin, Clozapine, Colistin (Sulphate & Sulphomethate Na), Cyanocobalamin, Cyclophosphamide, Dicloxacillin (Na), Ethinyloestradiol, Floxacillin (Na), Fosphenytoin, Estodene, Glibornuride, Gliquidone, Hydroxocobalamin, Ichthammol, Iron Dextran, Iron Salts, Iron Sorbitol, Mecillinam, Mecobalamin, Nafcillin, Oxacillin, Paracetamol, Phenobarbitone, Phenytoin (Na), Piperacillin (Na),pivmecillinam (HCl), Primidone, Procaine Penicillin, Promethazine (HCl),rifampicin, Sulfapyridine, Tolbutamide, Warfarin (Na).
Side effects of Chloramphenicol :Encephalopathy, Pseudomembranous Colitis, Anemia, Urticaria, Anemia, Thrombocytopenia, Hepatitis, Ototoxicity, Peripheral Neuropathy, Optic Neuritis, Hemolytic Reactions, Interstitial Nephritis, Headache, Nausea, Vomiting, Maculopapular Rash, Stomatitis, Confusion, Pruritus, Depression, Glossitis, Delirium, Transient Stinging.

INTERACTIONS OF CHLORAMPHENICOL


How Chloramphenicol will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chloramphenicol will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Chloramphenicol

No Studies Found