Medicine : Cefironev (15gm)

Name:Cefironev (15gm)
Type:Injection
Manufacturer:Piramal Healthcare
Generic Use:Ceftriaxone , Vancomycin
Composition:Ceftriaxone(1gm) , Vancomycin(0.5gm)
Substitutes:cefironev , cefironev (15gm) , cefironev , cefironev (15gm)


Generic ( Ceftriaxone )



Typical use Of Ceftriaxone :Meningitis, Septicaemia, Typhoid, UTI, Proplylaxis In Surgical Infections.
Mechanism of action of Ceftriaxone :Ceftriaxone Works By Inhibiting The Mucopeptide Synthesis In The Bacterial Cell Wall. The Beta-lactam Moiety Of Ceftriaxone Binds To Carboxypeptidases, Endopeptidases, And Transpeptidases In The Bacterial Cytoplasmic Membrane. These Enzymes Are Involved In Cell-wall Synthesis And Cell Division. By Binding To These Enzymes, Ceftriaxone Results In The Formation Of Defective Cell Walls And Cell Death.
Drug Interaction of Ceftriaxone :Ceftriaxone (Na) Is Known To Interact With Other Drugs Like Alcohol And Probenecid.These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Ceftriaxone :Jaundice, Eosinophilia, Leucopenia, Neutropenia, Thrombocytosis, Erythema Multiforme, Agranulocytosis, Pseudomembranous Colitis, Loose Stools, Nausea, Vomiting, Diarrhea, Maculopapular Rash, Urticaria, Pruritus.

INTERACTIONS OF CEFTRIAXONE


How Ceftriaxone will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Ceftriaxone will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ceftriaxone

No Studies Found






Generic ( Vancomycin )



Typical use Of Vancomycin :Acute Leukemia, Bacteremia, Brain Abscesses, Chronic Myeloid Leukaemia, Colitis, Constipation And Bowel Evacuation, Endocarditis, Endocarditis Prophylaxis, Endocarditis Treatment, Meningitis, Peritonitis, Persistant Neutropenia In Advanced Hiv Infection.
Mechanism of action of Vancomycin :Vancomycin Prevents Incorporation Of N-acetylmuramic Acid (NAM)- And N-acetylglucosamine (NAG)-peptide Subunits From Being Incorporated Into The Peptidoglycan Matrix; Which Forms The Major Structural Component Of Gram-positive Cell Walls. The Large Hydrophilic Molecule Is Able To Form Hydrogen Bond Interactions With The Terminal D-alanyl-D-alanine Moieties Of The NAM/NAG-peptides. This Binding Of Vancomycin To The D-Ala-D-Ala Prevents The Incorporation Of The NAM/NAG-peptide Subunits Into The Peptidoglycan Matrix And Alters Bacterial-cell-membrane Permeability And RNA Synthesis.
Drug Interaction of Vancomycin :Vancomycin Is Known To Interact With Other Drugs Like Amphotericin B, Cyclosporin A, Gentamicin, Metformin (HCl), Netilmicin (Sulphate), Oxaliplatin, Streptomycin, Tobramycin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Vancomycin :Nephrotoxicity, Renal Damage, Uremia, Hematuria, Proteinuria, Fever, Redness, Hypotension, Flushing, Urticarial Skin Rash, Eosinophilia, Red Man Syndrome.

INTERACTIONS OF VANCOMYCIN


How Vancomycin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Vancomycin will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Vancomycin

No Studies Found