Medicine : Aubril (60ml)

Name:Aubril (60ml)
Type:Syrup
Manufacturer:Novartis Pharmaceuticals Ltd
Generic Use:Sulfadiazine , Trimethoprim
Composition:Sulfadiazine(205 Mg) , Trimethoprim(45mg /5ml)
Substitutes:aubril (60ml) , aubril (60ml)


Generic ( Sulfadiazine )



Typical use Of Sulfadiazine :Bacterial Infections, Including Infections Of The Lungs, Skin, Blood, Female Reproductive Organs
Mechanism of action of Sulfadiazine :Sulphadiazine Has Bacteriostatic Effect On A Wide Range Of Gram-positive And Gram-negative Organisms. It Interferes With Nucleic Acid Synthesis Thus Blocking Conversion Of PABA To The Coenzyme Dihydrofolic Acid.
Drug Interaction of Sulfadiazine :Sulphadiazine Is Known To Interact With Other Drugs Like Ascorbic Acid,Chlorpropamide, Methotrexate, Phenytoin (Na), Procaine, Pyrimethamine,Tolbutamide, Torasemide, Trimethoprim, Warfarin (Na).
Side effects of Sulfadiazine :Nausea, Stomach Upset, Skin Rash, Acute Toxicity.

INTERACTIONS OF SULFADIAZINE


How Sulfadiazine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Sulfadiazine will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Sulfadiazine

No Studies Found






Generic ( Trimethoprim )



Typical use Of Trimethoprim :Benign Gastric And Duodenal Ulceration And Chronic Gastritis, Prophylaxis Of NSAID-induced Gastric And Duodenal Ulceration, Prophylaxis Of UTI, Respiratory Tract Infections, UTI.
Mechanism of action of Trimethoprim :Trimethoprim Binds To Dihydrofolate Reductase And Inhibits The Reduction Of Dihydrofolic Acid (DHF) To Tetrahydrofolic Acid (THF). THF Is An Essential Precursor In The Thymidine Synthesis Pathway And Interference With This Pathway Inhibits Bacterial DNA Synthesis.
Drug Interaction of Trimethoprim :Trimethoprim Is Known To Interact With Other Drugs Like Amantadine, Azathioprine, Bendrofluazide, Clozapine, Colistin (Sulphate & Sulphomethate Na), Cyclosporin A, Dapsone, Digoxin, Ganciclovir (Na), Glipizide, Hydrochlorothiazide, Lamivudine, Metformin (HCl), Methotrexate, Norgestimate, Para Aminobenzoic Acid, Phenytoin (Na), Pyrimethamine, Rifampicin, Silver Sulphadiazine, Sulfadoxine, Sulphadiazine, Sulphamethoxazole, Warfarin (Na), Zalcitabine, Zidovudine. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Trimethoprim :Vomiting, Depression, Psychosis, Mania, Facial Edema.

INTERACTIONS OF TRIMETHOPRIM


How Trimethoprim will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Trimethoprim will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Trimethoprim

No Studies Found