Generic ( Amikacin )

Typical use Of Amikacin :It Has The Widest Spectrum Of Activity, Including Many Organisms Resistant To Other Aminoglycosides. Pseudomonas, Proteus And Staph. Infections. Hospital Acquired Gram-negative Bacillary Infections. Tuberculosis.
Mechanism of action of Amikacin : Amikacin "irreversibly" Bind To Specific 30S-subunit Proteins And 16S RRNA. Amikacin Inhibits Protein Synthesis By Binding To The 30S Ribosomal Subunit To Prevent The Formation Of An Initiation Complex With Messenger RNA. Specifically Amikacin Binds To Four Nucleotides Of 16S RRNA And A Single Amino Acid Of Protein S12. This Interferes With Decoding Site In The Vicinity Of Nucleotide 1400 In 16S RRNA Of 30S Subunit. This Region Interacts With The Wobble Base In The Anticodon Of TRNA. This Leads To Interference With The Initiation Complex, Misreading Of MRNA So Incorrect Amino Acids Are Inserted Into The Polypeptide Leading To Nonfunctional Or Toxic Peptides And The Breakup Of Polysomes Into Nonfunctional Monosomes.
Drug Interaction of Amikacin :Amikacin Is Known To Interact With Other Drugs Like Amphotericin B, Cefotaxime, Ethacrynic Acid, Frusemide Or Furosemide, Oxaliplatin, Pancuronium (Br).
Side effects of Amikacin :Nephrotoxicity, Neuromuscular Blockage, Renal Tubular Acidosis, Vertigo, Ataxia, Tinnitus, Sense Of Fulness In Ears, Ototoxicity, Circumoral Paresthesia, Pyuria, Proteinuria, Azotemia.


How Amikacin will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Amikacin will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Amikacin

No Studies Found