Medicine : Aerolife Spacer

Name:Aerolife Spacer
Manufacturer:Zydus Cadila Healthcare Ltd (german Remedies)
Generic Use:Topotecan
Composition:Topotecan(1 Mg)
Substitutes:hycamtin (1mg) , aerolife spacer

Generic ( Topotecan )

Typical use Of Topotecan :Ovarian Cancer, Small Cell Lung Cancer.
Mechanism of action of Topotecan :Topotecan Binds To The Topoisomerase I-DNA Complex And Prevents Religation Of These Single Strand Breaks. This Ternary Complex Interferes With The Moving Replication Fork, Which Leads To The Induction Of Replication Arrest And Lethal Double-stranded Breaks In DNA. The Formation Of This Ternary Complex Eventually Leads To Apoptosis (programmed Cell Death). Topotecan Mimics A DNA Base Pair And Binds At The Site Of DNA Cleavage By Intercalatingbetween The Upstream (?1) And Downstream (+1) Base Pairs. Intercalation Displaces The Downstream DNA, Thus Preventing Religation Of The Cleaved Strand.
Drug Interaction of Topotecan :Topotecan Is Known To Interact With Other Drugs Like Amiodarone, Atorvastatin, Carboplatin, Carvedilol, Clarithromycin,Darunavir, Dipyridamole, Erythromycin, Filgrastim, Itraconazole, Ketoconazole, Natalizumab, Nicardipine, Pantoprazole. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Topotecan :Thrombocytopenia, Hyperbilirubinemia, Fatigue, Alopecia, Malaise, GI Disturbance.


How Topotecan will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Topotecan will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Topotecan

No Studies Found