Medicine : Acucort (250mg)

Name:Acucort (250mg)
Type:Injection
Manufacturer:Macleods Pharmaceuticals Ltd
Generic Use:Hydrocortisone
Composition:Hydrocortisone(250 Mg)
Substitutes:acucort (250mg)


Generic ( Hydrocortisone )



Typical use Of Hydrocortisone :Replacement Therapy: Adrenal Insufficiency. Adrenogenital Syndrome.Nonendocrine Diseases: Rheumatoid Arthirits. Osteoarthritis, Acute Gouty Arthirits.Collagen Diseases E.g. Systemic Lupus Erythematosus, Polyarteritis Nodosa, Dermatomyositis, Nephritic Syndrome, Glomerulonephritis And Related Diseases.Severe Allergic Reactions E.g. Anaphylaxis, Angioneurotic Edema, Urticaria And Serum Sickness And Related Diseases.Autoimmune Diseases E.g. Haemolytic Anaemia, Idiopathic Thrombocytopenic Purpura, Active Chronic Hepatitis And Related Diseases.Other Lung Diseases E.g. Pulmonary Edema, Accelerate Lung Maturation And Surfactant Production In The Foetus And Prevent Respiratory Distress Syndrome At Birth.Infective Diseases E.g. Severe Forms Of Tuberculosis, Severe Lepra Reaction, Certain Forms Of Bacterial Meningitis And Pneumocystis Carinii Pneumonia With Hypoxia In AIDS Patients Along With Proper Antibiotic Cover.Eye Diseases E.g. Inflammatory Ocular Diseases, Allergic Conjunctivitis, Iritis, Iridocyclitis, Keratitis, Retinitis, Optic Neuritis, Uveitis.Skin Diseases E.g. Eczematous Skin Diseases. Pemphigus Vulgaris, Exfoliative Dermatitis, Stevens Johnson Syndrome.Intestinal Diseases E.g. Ulcerative Colitis, Crohns Disease, Coeliac Disease Are Chronic Inflammatory Intestinal Diseases.Cerebral Edema.Malignancies E.g. Acute Lymphatic Leukaemia, Hodgkins And Other Lymphomas. Hormone Responsive Breast Carcinoma.Organ Transplantation And Skin Allograft.Septic Shock.Thyroid Storm.
Mechanism of action of Hydrocortisone :Hydrocortisone Binds To The Cytosolic Glucocorticoid Receptor. After Binding The Receptor The Newly Formed Receptor-ligand Complex Translocates Itself Into The Cell Nucleus, Where It Binds To Many Glucocorticoid Response Elements (GRE) In The Promoter Region Of The Target Genes. The DNA Bound Receptor Then Interacts With Basic Transcription Factors, Causing The Increase In Expression Of Specific Target Genes. The Anti-inflammatory Actions Of Corticosteroids Are Thought To Involve Lipocortins, Phospholipase A2 Inhibitory Proteins Which, Through Inhibition Arachidonic Acid, Control The Biosynthesis Of Prostaglandins And Leukotrienes. Specifically Glucocorticoids Induce Lipocortin-1 (annexin-1) Synthesis, Which Then Binds To Cell Membranes Preventing The Phospholipase A2 From Coming Into Contact With Its Substrate Arachidonic Acid. This Leads To Diminished Eicosanoid Production.
Drug Interaction of Hydrocortisone :Hydrocortisone Is Known To Interact With Other Drugs Like Aminoglutethimide, Amobarbital, Amphotericin B, Ascorbic Acid, Aspirin, Carbamazepine, Frusemide Or Furosemide, Gentamicin, Ipilimumab, Lofexidine, Metyrosine, Natamycin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Hydrocortisone :Convulsions, GI Bleeding, Telangiectasia, Striae, Glaucoma, Cataract, Pancreatitis, Hypersensitivity Reactions, Osteoporosis, Psychosis, Increased Intracranial Pressure, Growth Retardation, Glucose Intolerance, Epidermal Thinning, Vertebral Fractures, Avascular Necrosis, Papilloedema, Opthalmic Fungal Or Viral Disease, Dendritic Corneal Ulcers, Thromboembolic Disorder, Long Bone Fractures, Hypokalemic Alkalosis, Anaphylactoid Reactions, Addisonian Crises, CHF, Opportunistic Infections, Acute Pancreatitis, Insomnia, Irritation, Allergic Reactions, Itching, Burning, Depression, Weight Gain, Acne, Euphoria, Menstrual Irregularity, Perioral Dermatitis.

INTERACTIONS OF HYDROCORTISONE


How Hydrocortisone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Hydrocortisone will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Hydrocortisone

No Studies Found