Medicine : Acitrom (2mg)

Name:Acitrom (2mg)
Type:Tablet
Manufacturer:Abbott India Ltd
Generic Use:Acenocoumarol , Nicoumalone , Multivitamin
Composition:Acenocoumarol(2 Mg) , Nicoumalone(2 Mg) , Multivitamin(2mg)
Substitutes:acitrom (2mg) , acitrom (2mg) , acitrom (2mg)


Generic ( Acenocoumarol )



Typical use Of Acenocoumarol :Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Embolisation.
Mechanism of action of Acenocoumarol :Acenocoumarol Inhibits Vitamin K Reductase, Resulting In Depletion Of The Reduced Form Of Vitamin K (vitamin KH2). As Vitamin K Is A Cofactor For The Carboxylation Of Glutamate Residues On The N-terminal Regions Of Vitamin K-dependent Clotting Factors, This Limits The Gamma-carboxylation And Subsequent Activation Of The Vitamin K-dependent Coagulant Proteins. The Synthesis Of Vitamin K-dependent Coagulation Factors II, VII, IX, And X And Anticoagulant Proteins C And S Is Inhibited Resulting In Decreased Prothrombin Levels And A Decrease In The Amount Of Thrombin Generated And Bound To Fibrin. This Reduces The Thrombogenicity Of Clots.
Drug Interaction of Acenocoumarol :Bismuth Carbonate And Mg Reduce Absorption. Cimetidine, Allopurinol, Diuretics And Other Oral Anticoagulants Enhance Effect. Vit K Reverses Effect. Potentiated By NSAIDs, Amiodarone, Antibacterial Agents Eg, Co-trimoxazole, Cephalosporins, Erythromycin, Quinolone Antibiotics, Chloramphenicol, Doxycycline, INH And Neomycin. Rifampicin, Barbiturates And Griseofulvin Diminish Effect.
Side effects of Acenocoumarol :Alopecia, Fever, Nausea, Vomiting, Diarrhoea, Skin Rash, Cholestatic Liver Damage, Haemorrhage.

INTERACTIONS OF ACENOCOUMAROL


How Acenocoumarol will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Acenocoumarol will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Acenocoumarol

No Studies Found






Generic ( Nicoumalone )



Typical use Of Nicoumalone :Information Not Available.
Mechanism of action of Nicoumalone :Nicoumalone Inhibits Vitamin K Reductase, Resulting In Depletion Of The Reduced Form Of Vitamin K (vitamin KH2). As Vitamin K Is A Cofactor For The Carboxylation Of Glutamate Residues On The N-terminal Regions Of Vitamin K-dependent Clotting Factors, This Limits The Gamma-carboxylation And Subsequent Activation Of The Vitamin K-dependent Coagulant Proteins. The Synthesis Of Vitamin K-dependent Coagulation Factors II, VII, IX, And X And Anticoagulant Proteins C And S Is Inhibited Resulting In Decreased Prothrombin Levels And A Decrease In The Amount Of Thrombin Generated And Bound To Fibrin. This Reduces The Thrombogenicity Of Clots.
Drug Interaction of Nicoumalone :Bismuth Carbonate And Mg Reduce Absorption. Cimetidine, Allopurinol, Diuretics And Other Oral Anticoagulants Enhance Effect. Vit K Reverses Effect. Potentiated By NSAIDs, Amiodarone, Antibacterial Agents Eg, Co-trimoxazole, Cephalosporins, Erythromycin, Quinolone Antibiotics, Chloramphenicol, Doxycycline, INH And Neomycin. Rifampicin, Barbiturates And Griseofulvin Diminish Effect.
Side effects of Nicoumalone :Alopecia, Fever, Nausea, Vomiting, Diarrhoea, Skin Rash, Cholestatic Liver Damage, Haemorrhage.

INTERACTIONS OF NICOUMALONE


How Nicoumalone will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Nicoumalone will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Nicoumalone

No Studies Found






Generic ( Multivitamin )



Typical use Of Multivitamin :Multivitamins Are Also Used To Treat Vitamins Deficiencies Caused By Illness, Pregnancy, Poor Nutrition, Digestive Disorders, Certain Medications.
Mechanism of action of Multivitamin :Not Known
Drug Interaction of Multivitamin :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Multivitamin :Upset Stomach, Headache, Unusual Or Unpleasant Taste In Mouth.

INTERACTIONS OF MULTIVITAMIN


How Multivitamin will impact on Pregnancy ?

There Are No Studies Available Regarding Its Use During Pregnancy. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Multivitamin will impact during lactation(breastfeeding) ?

There Are No Studies Available Regarding Its Use During Lactation. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Multivitamin

No Studies Found