Medicine : Platikem (20mg)

Name:Platikem (20mg)
Manufacturer:Alkem Laboratories Ltd
Generic Use:Cisplatin
Composition:Cisplatin(20 Mg)

Generic ( Cisplatin )

Typical use Of Cisplatin :Bladder Carcinoma, Metastatic Germ Cell Cancers (seminoma And Teratoma), Metastatic Ovarian Carcinoma, Metastatic Testicular Cancer, Non-small Cell Lung Carcinoma, Small Cell Lung Cancer.
Mechanism of action of Cisplatin :Cisplatin Work By Three Different Mechanisms: 1) Attachment Of Alkyl Groups To DNA Bases, Resulting In The DNA Being Fragmented By Repair Enzymes In Their Attempts To Replace The Alkylated Bases, Preventing DNA Synthesis AndRNA Transcription From The Affected DNA. 2) DNA Damage Via The Formation Of Cross-links (bonds Between Atoms In The DNA) Which Prevents DNA From Being Separated For Synthesis Or Transcription. 3) The Induction Of Mispairing Of The Nucleotides Leading To Mutations.
Drug Interaction of Cisplatin :Cisplatin Is Known To Interact With Other Drugs Like Amphotericin B, Bleomycin, Capreomycin, Diazoxide, Etoposide, Fluorouracil, Fosphenytoin, Frusemide Or Furosemide, Gallium Nitrate, Gemcitabine, Gentamicin, Hydralazine (HCl), Ifosfamide, Mannitol, Netilmicin (Sulphate), Paclitaxel, Podophyllum, Propranolol (HCl), Rituximab, Tacrolimus, Tobramycin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Cisplatin :Neuropathy, Hypersensitivity Reactions, Ototoxicity, Reduction In Creatinine Clearance, Elevation In Serum Creatinine, Vascular Toxicity.


How Cisplatin will impact on Pregnancy ?

Information Not Available.

How Cisplatin will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Cisplatin

Information Not Available.